NHP2 downregulation counteracts h TR ‐mediated activation of the DNA damage response at ALT telomeres-Reference-Cited by-同舟云学术

NHP2 downregulation counteracts h TR ‐mediated activation of the DNA damage response at ALT telomeres

Published:2021-02-17 Issue:6 Volume:40 Page:
ISSN:0261-4189
Container-title:The EMBO Journal
language:en
Short-container-title:EMBO J

Author:

Raghunandan Maya¹,Geelen Dan¹,Majerova Eva¹,Decottignies Anabelle¹^ORCID

Affiliation:

1. Genetic and Epigenetic Alterations of Genomes de Duve Institute Faculty of Pharmacy and Biomedical Sciences Université catholique de Louvain Brussels Belgium

Publisher

EMBO

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

Link

https://onlinelibrary.wiley.com/doi/pdf/10.15252/embj.2020106336

Reference97 articles.

1. Telomere length regulates TERRA levels through increased trimethylation of telomeric H3K9 and HP1α

2. Telomeres and telomerase in cancer

3. Lack of Telomerase Gene Expression in Alternative Lengthening of Telomere Cells Is Associated with Chromatin Remodeling of the hTR and hTERT Gene Promoters

4. NHP2 deficiency impairs rRNA biogenesis and causes pulmonary fibrosis and Høyeraal–Hreidarsson syndrome

5. Structure and function of telomeres

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1. Telomere-related DNA damage response pathways in cancer therapy: prospective targets;Frontiers in Pharmacology;2024-06-07

2. Maintenance of R-loop structures by phosphorylated hTERT preserves genome integrity;Nature Cell Biology;2024-05-28

3. Novel pathological variants of NHP2 affect N-terminal domain flexibility, protein stability, H/ACA Ribonucleoprotein (RNP) complex formation and telomerase activity;Human Molecular Genetics;2023-07-13

4. A novel mutation (p.Y24N) in NHP2 leads to idiopathic pulmonary fibrosis and lung carcinoma chronic obstructive lung disease by disrupting the expression and nucleocytoplasmic localization of NHP2;Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease;2023-06

5. Many Functions of Telomerase Components: Certainties, Doubts, and Inconsistencies;International Journal of Molecular Sciences;2022-12-02