SIRT 2 induces the checkpoint kinase BubR1 to increase lifespan-Reference-Cited by-同舟云学术

SIRT 2 induces the checkpoint kinase BubR1 to increase lifespan

Published:2014-05-13 Issue:13 Volume:33 Page:1438-1453
ISSN:0261-4189
Container-title:The EMBO Journal
language:en
Short-container-title:EMBO J

Author:

North Brian J¹,Rosenberg Michael A²,Jeganathan Karthik B³,Hafner Angela V¹,Michan Shaday¹,Dai Jing²,Baker Darren J³,Cen Yana⁴,Wu Lindsay E⁵,Sauve Anthony A⁴,Deursen Jan M³,Rosenzweig Anthony²,Sinclair David A¹⁵

Affiliation:

1. Department of Genetics Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School Boston MA USA

2. Cardiovascular Division Beth Israel Deaconess Medical Center Harvard Medical School Boston MA USA

3. Department of Pediatric and Adolescent Medicine Mayo Clinic College of Medicine Rochester MN USA

4. Department of Pharmacology Weill Medical College of Cornell University New York NY USA

5. Department of Pharmacology School of Medicine The University of New South Wales Sydney NSW Australia

Publisher

EMBO

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

Link

https://onlinelibrary.wiley.com/doi/pdf/10.15252/embj.201386907

Reference51 articles.

1. Effect of aging on the electrocardiogram

2. BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice

3. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

4. Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan

5. Efficient method to generate single-copy transgenic mice by site-specific integration in embryonic stem cells

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