Affiliation:
1. Stem Cell Biochemistry Unit, National Institute of Dental and Craniofacial Research National Institutes of Health Bethesda MD USA
Abstract
The CUL4 paralogs CUL4A and CUL4B assemble into structurally similar multisubunit ubiquitin E3 ligases (CRL4A/B) that regulate diverse aspects of cell biology. New work in this issue of The EMBO Journal shows that the longer N‐terminal tail of CUL4B tells these molecular twins apart, by promoting the formation of paralog‐specific CRL4B complexes that control cytoskeletal processes during mitosis and brain development.
Funder
National Institute of Dental and Craniofacial Research
Publisher
Springer Science and Business Media LLC
Subject
General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience