Inhibition of CPAP –tubulin interaction prevents proliferation of centrosome‐amplified cancer cells

Author:

Mariappan Aruljothi12ORCID,Soni Komal34,Schorpp Kenji5,Zhao Fan678,Minakar Amin9,Zheng Xiangdong678,Mandad Sunit101112,Macheleidt Iris13,Ramani Anand114,Kubelka Tomáš4,Dawidowski Maciej3415,Golfmann Kristina2,Wason Arpit2,Yang Chunhua16,Simons Judith2,Schmalz Hans‐Günther9,Hyman Anthony A17,Aneja Ritu16,Ullrich Roland2,Urlaub Henning1011,Odenthal Margarete13ORCID,Büttner Reinhardt13,Li Haitao678ORCID,Sattler Michael34ORCID,Hadian Kamyar5,Gopalakrishnan Jay1214ORCID

Affiliation:

1. Institute für Humangenetik Universitätsklinikum Düsseldorf, Heinrich‐Heine‐Universität Düsseldorf Germany

2. Center for Molecular Medicine of the University of Cologne Cologne Germany

3. Institute of Structural Biology Helmholtz Zentrum München Neuherberg Germany

4. Biomolecular NMR at Center for Integrated Protein Science Munich and Department Chemie Technische Universität München Garching Germany

5. Assay Development and Screening Platform Institute of molecular Toxicology and Pharmacology Helmholtz Zentrum München—German Research Center for Environmental Health Neuherberg Germany

6. Department of Basic Medical Sciences Center for Structural Biology School of Medicine Beijing China

7. MOE Key Laboratory of Protein Sciences School of Life Sciences Beijing China

8. Tsinghua‐Peking Center for Life Sciences Tsinghua University Beijing China

9. Department of Chemistry University of Cologne Cologne Germany

10. Bioanalytical Mass Spectrometry Group Max Planck Institute for Biophysical Chemistry Göttingen Germany

11. Bioanalytics University Medical Center Goettingen Goettingen Germany

12. Department of Neuro‐ and Sensory Physiology University Medical Center Göttingen Göttingen Germany

13. Institute of Pathology and Center for Molecular Medicine of the University of Cologne CologneGermany

14. IUF‐Leibniz Research Institute for Environmental Medicine Düsseldorf Germany

15. Department of Drug Technology and Pharmaceutical Biotechnology Faculty of Pharmacy Medical University of Warsaw Warsaw Poland

16. Department of Biology Georgia State University Atlanta GA USA

17. Max Planck Institute of Molecular Cell Biology and Genetics Dresden Germany

Funder

Human Frontier Science Program

Deutsche Forschungsgemeinschaft

Publisher

EMBO

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

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