PIP2 depletion and altered endocytosis caused by expression of Alzheimer's disease‐protective variant PLCγ2 R522-Reference-Cited by-同舟云学术

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PIP2 depletion and altered endocytosis caused by expression of Alzheimer's disease‐protective variant PLCγ2 R522

Published:2021-07-13 Issue:17 Volume:40 Page:
ISSN:0261-4189
Container-title:The EMBO Journal
language:en
Short-container-title:EMBO J

Author:

Maguire Emily¹,Menzies Georgina E¹²^ORCID,Phillips Thomas¹,Sasner Michael³,Williams Harriet M³,Czubala Magdalena A⁴,Evans Neil¹,Cope Emma L²,Sims Rebecca⁵,Howell Gareth R³,Lloyd‐Evans Emyr²,Williams Julie¹⁵,Allen Nicholas D²^ORCID,Taylor Philip R¹⁴^ORCID

Affiliation:

1. UK Dementia Research Institute at Cardiff Cardiff UK

2. School of Biosciences Cardiff University Cardiff UK

3. The Jackson Laboratory Bar Harbor ME USA

4. Systems Immunity University Research Institute Cardiff UK

5. MRC Centre for Neuropsychiatric Genetics & Genomics Cardiff UK

Funder

UK Dementia Research Institute

Innovative Medicines Initiative

Alzheimer’s Research UK

Medical Research Council

National Institute on Aging

Publisher

EMBO

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

Link

https://onlinelibrary.wiley.com/doi/pdf/10.15252/embj.2020105603

Reference60 articles.

1. Alzheimer’s-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia

2. Localized Biphasic Changes in Phosphatidylinositol-4,5-Bisphosphate at Sites of Phagocytosis

3. Localized Biphasic Changes in Phosphatidylinositol-4,5-Bisphosphate at Sites of Phagocytosis

4. Phosphatidylinositol 4,5-bisphosphate and Arf6-regulated membrane traffic

5. Dectin-1 Is A Major β-Glucan Receptor On Macrophages

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1. The role of macrophage plasticity in neurodegenerative diseases;Biomarker Research;2024-08-13

2. Alzheimer’s disease-associated protective variant Plcg2-P522R modulates peripheral macrophage function in a sex-dimorphic manner and confers functional advantage in female mice;2024-06-01

3. The hypermorphic PLCγ2 S707Y variant dysregulates microglial cell function – Insight into PLCγ2 activation in brain health and disease, and opportunities for therapeutic modulation;Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease;2024-02

4. Mutant huntingtin confers cell-autonomous phenotypes on Huntington’s disease iPSC-derived microglia;Scientific Reports;2023-11-22

5. The hypermorphic PLCγ2 S707Y variant dysregulates microglial cell function – insight into PLCγ2 activation in brain health and disease, and opportunities for therapeutic modulation;2023-11-02

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