GSTZ 1‐1 Deficiency Activates NRF 2/ IGF 1R Axis in HCC via Accumulation of Oncometabolite Succinylacetone-Reference-Cited by-同舟云学术

GSTZ 1‐1 Deficiency Activates NRF 2/ IGF 1R Axis in HCC via Accumulation of Oncometabolite Succinylacetone

Published:2019-06-28 Issue:15 Volume:38 Page:
ISSN:0261-4189
Container-title:The EMBO Journal
language:en
Short-container-title:EMBO J

Author:

Yang Fan¹²,Li Jingjing¹,Deng Haijun¹,Wang Yihao³,Lei Chong¹,Wang Qiujie¹,Xiang Jin¹,Liang Li¹,Xia Jie¹,Pan Xuanming¹,Li Xiaosong²,Long Quanxin¹,Chang Lei³,Xu Ping³,Huang Ailong¹^ORCID,Wang Kai¹^ORCID,Tang Ni¹^ORCID

Affiliation:

1. Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education) Department of Infectious Diseases The Second Affiliated Hospital Institute for Viral Hepatitis Chongqing Medical University Chongqing China

2. Department of Infectious Diseases The First Affiliated Hospital Chongqing Medical University Chongqing China

3. State Key Laboratory of Proteomics Beijing Proteome Research Center National Center for Protein Sciences (Beijing) Beijing Institute of Lifeomics Beijing China

Funder

National Natural Science Foundation of China

Ministry of Science and Technology of the People's Republic of China

Natural Science Foundation of Chongqing

Publisher

EMBO

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

Link

https://onlinelibrary.wiley.com/doi/pdf/10.15252/embj.2019101964

Reference44 articles.

1. Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling