C9orf72 ALS/FTD dipeptide repeat protein levels are reduced by small molecules that inhibit PKA or enhance protein degradation-Reference-Cited by-同舟云学术

C9orf72 ALS/FTD dipeptide repeat protein levels are reduced by small molecules that inhibit PKA or enhance protein degradation

Published:2021-11-18 Issue:1 Volume:41 Page:
ISSN:0261-4189
Container-title:The EMBO Journal
language:en
Short-container-title:The EMBO Journal

Author:

Licata Nausicaa V¹^ORCID,Cristofani Riccardo²^ORCID,Salomonsson Sally³⁴^ORCID,Wilson Katherine M³⁴,Kempthorne Liam³⁴^ORCID,Vaizoglu Deniz³⁴^ORCID,D’Agostino Vito G¹^ORCID,Pollini Daniele¹^ORCID,Loffredo Rosa¹^ORCID,Pancher Michael⁵^ORCID,Adami Valentina⁵^ORCID,Bellosta Paola¹⁶^ORCID,Ratti Antonia⁷⁸^ORCID,Viero Gabriella⁹^ORCID,Quattrone Alessandro¹^ORCID,Isaacs Adrian M³⁴^ORCID,Poletti Angelo²^ORCID,Provenzani Alessandro¹^ORCID

Affiliation:

1. Department of Cellular, Computational and Integrative Biology University of Trento Trento Italy

2. Dipartimento di Scienze Farmacologiche e Biomolecolari Università degli Studi di Milano Milan Italy

3. Department of Neurodegenerative Disease UCL Queen Square Institute of Neurology London UK

4. UK Dementia Research Institute at UCL UCL Queen Square Institute of Neurology London UK

5. HTS Core Facility, Department of Cellular, Computational and Integrative Biology University of Trento Trento Italy

6. Department of Medicine NYU at Grossman School of Medicine NY USA

7. Department of Neurology Stroke Unit and Laboratory of Neuroscience Istituto Auxologico Italiano, IRCCS Milan Italy

8. Dipartimento di Biotecnologie Mediche e Medicina Traslazionale Università degli Studi di Milano Milan Italy

9. Institute of Biophysics CNR Unit at Trento Trento Italy

Funder

Fondazione Italiana di Ricerca per la Sclerosi Laterale Amiotrofica

Fondazione Telethon

Kennedy's Disease Association

Ministero dell’Istruzione, dell’Università e della Ricerca

Agenzia Italiana del Farmaco, Ministero della Salute

Fondazione Cariplo

H2020 European Research Council

Publisher

EMBO

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

Link

https://onlinelibrary.wiley.com/doi/pdf/10.15252/embj.2020105026

Reference109 articles.

1. Correction of amyotrophic lateral sclerosis related phenotypes in induced pluripotent stem cell-derived motor neurons carrying a hexanucleotide expansion mutation in C9orf72 by CRISPR/Cas9 genome editing using homology-directed repair

2. A Small Molecule Screen Identifies an Inhibitor of DNA Repair Inducing the Degradation of TFIIH and the Chemosensitization of Tumor Cells to Platinum

3. Unconventional Translation of C9ORF72 GGGGCC Expansion Generates Insoluble Polypeptides Specific to c9FTD/ALS

4. Impairment of the Ubiquitin-Proteasome System by Protein Aggregation

5. In Vivo Translatome Profiling in Spinal Muscular Atrophy Reveals a Role for SMN Protein in Ribosome Biology

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