Reduced ER–mitochondria connectivity promotes neuroblastoma multidrug resistance

Author:

Çoku Jorida1,Booth David M2,Skoda Jan34ORCID,Pedrotty Madison C5,Vogel Jennifer6,Liu Kangning5,Vu Annette5,Carpenter Erica L7,Ye Jamie C5,Chen Michelle A5,Dunbar Peter5,Scadden Elizabeth5ORCID,Yun Taekyung D8,Nakamaru‐Ogiso Eiko910,Area‐Gomez Estela8ORCID,Li Yimei11,Goldsmith Kelly C12,Reynolds C Patrick13,Hajnoczky Gyorgy2ORCID,Hogarty Michael D510ORCID

Affiliation:

1. Cancer Biology Program Perelman School of Medicine University of Pennsylvania Philadelphia PA USA

2. MitoCare Center Department of Pathology Anatomy & Cell Biology Thomas Jefferson University Philadelphia PA USA

3. Department of Experimental Biology Faculty of Science Masaryk University Brno Czech Republic

4. International Clinical Research Center St. Anne's University HospitalBrno Czech Republic

5. Division of Oncology and Center for Childhood Cancer Research The Children's Hospital of Philadelphia Philadelphia PA USA

6. Department of Radiation Oncology Perelman School of Medicine University of Pennsylvania Philadelphia PA USA

7. Department of Medicine Perelman School of Medicine University of Pennsylvania Philadelphia PA USA

8. Department of Neurology Columbia University Irving Medical Center New York NY USA

9. Mitochondrial Medicine Frontier Program Division of Human Genetics The Children's Hospital of Philadelphia Philadelphia PA USA

10. Department of Pediatrics Perelman School of Medicine University of Pennsylvania Philadelphia PA USA

11. Department of Biostatistics Perelman School of Medicine University of Pennsylvania Philadelphia PA USA

12. Department of Pediatrics Emory University School of Medicine Atlanta GA USA

13. TTUHSC Cancer Center Texas Tech University Health Sciences Center Lubbock TX USA

Funder

National Cancer Institute

National Institute of General Medical Sciences

Grantová Agentura České Republiky

Alex's Lemonade Stand Foundation for Childhood Cancer

St. Baldrick's Foundation

CURE Childhood Cancer

Publisher

EMBO

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

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