Small molecule inhibitors reveal an indispensable scaffolding role of RIPK 2 in NOD 2 signaling-Reference-Cited by-同舟云学术

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Small molecule inhibitors reveal an indispensable scaffolding role of RIPK 2 in NOD 2 signaling

Published:2018-07-19 Issue:17 Volume:37 Page:
ISSN:0261-4189
Container-title:The EMBO Journal
language:en
Short-container-title:EMBO J

Author:

Hrdinka Matous¹^ORCID,Schlicher Lisa¹,Dai Bing²,Pinkas Daniel M³,Bufton Joshua C³,Picaud Sarah³,Ward Jennifer A³⁴,Rogers Catherine³⁴,Suebsuwong Chalada⁵,Nikhar Sameer⁶,Cuny Gregory D⁶,Huber Kilian VM³⁴^ORCID,Filippakopoulos Panagis³,Bullock Alex N³,Degterev Alexei²^ORCID,Gyrd‐Hansen Mads¹^ORCID

Affiliation:

1. Nuffield Department of Clinical Medicine Ludwig Institute for Cancer Research University of Oxford Oxford UK

2. Department of Developmental, Molecular & Chemical Biology Tufts University School of Medicine Boston MA USA

3. Nuffield Department of Clinical Medicine Structural Genomics Consortium University of Oxford Oxford UK

4. Nuffield Department of Clinical Medicine Target Discovery Institute University of Oxford Oxford UK

5. Department of Chemistry University of Houston Houston TX USA

6. Department of Pharmacological and Pharmaceutical Sciences University of Houston Houston TX USA

Funder

Eshelman Institute for Innovation, University of North Carolina at Chapel Hill

Allergopharma

Novartis Pharma

Wellcome Trust

Takeda Pharmaceutical Company

Forskerakademiet

Ministerstvo Vnitra České Republiky

European Molecular Biology Organization

Ludwig Institute for Cancer Research

AbbVie

Bayer

Boehringer Ingelheim

Canada Foundation for Innovation

Genome Canada

Erzincan Üniversitesi

Meso Scale Diagnostics

Ontario Ministry of Economic Development and Innovation

Pfizer

Fundação de Amparo à Pesquisa do Estado de São Paulo

Myeloma UK

American Heart Association

National Institutes of Health

Publisher

EMBO

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

Link

https://onlinelibrary.wiley.com/doi/pdf/10.15252/embj.201899372

Reference67 articles.

1. A new functional assay for the diagnosis of X-linked inhibitor of apoptosis (XIAP) deficiency

2. Epidemiology and risk factors for IBD

3. Checkpoints in TNF-Induced Cell Death: Implications in Inflammation and Cancer

4. XIAP Regulates Cytosol-Specific Innate Immunity to Listeria Infection

5. Cellular Inhibitors of Apoptosis cIAP1 and cIAP2 Are Required for Innate Immunity Signaling by the Pattern Recognition Receptors NOD1 and NOD2

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1. Understanding the molecular mechanism of pathogenic variants of BIR2 domain in XIAP-deficient inflammatory bowel disease;Scientific Reports;2024-01-09

2. OTUD1 ameliorates cerebral ischemic injury through inhibiting inflammation by disrupting K63-linked deubiquitination of RIP2;Journal of Neuroinflammation;2023-11-27

3. RIPK2 inhibitors for disease therapy: Current status and perspectives;European Journal of Medicinal Chemistry;2023-11

4. Receptor Interacting Ser/Thr-Protein Kinase 2 as a New Therapeutic Target;Journal of Medicinal Chemistry;2023-10-19

5. Understanding the molecular mechanism of pathogenic variants of BIR2 domain in XIAP-deficient inflammatory bowel disease;2023-10-09

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