Pharmacological CDK4/6 inhibition reveals a p53‐dependent senescent state with restricted toxicity-Reference-Cited by-同舟云学术

Pharmacological CDK4/6 inhibition reveals a p53‐dependent senescent state with restricted toxicity

Published:2022-01-05 Issue:6 Volume:41 Page:
ISSN:0261-4189
Container-title:The EMBO Journal
language:en
Short-container-title:The EMBO Journal

Author:

Wang Boshi¹^ORCID,Varela‐Eirin Marta¹^ORCID,Brandenburg Simone M¹^ORCID,Hernandez‐Segura Alejandra¹,van Vliet Thijmen¹,Jongbloed Elisabeth M²,Wilting Saskia M²,Ohtani Naoko³^ORCID,Jager Agnes²,Demaria Marco¹^ORCID

Affiliation:

1. European Research Institute for the Biology of Ageing (ERIBA) University Medical Center Groningen (UMCG) Groningen The Netherlands

2. Department of Medical Oncology Erasmus MC Cancer Institute Erasmus University Medical Center Rotterdam The Netherlands

3. Graduate School of Medicine Osaka City University Osaka Japan

Funder

KWF Kankerbestrijding

Publisher

EMBO

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

Link

https://onlinelibrary.wiley.com/doi/pdf/10.15252/embj.2021108946

Reference53 articles.

1. A CDK4/6-Dependent Epigenetic Mechanism Protects Cancer Cells from PML-induced Senescence

2. Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging

3. CDK6 Antagonizes p53-Induced Responses during Tumorigenesis

4. Induction of the growth inhibitor IGF-binding protein 3 by p53

5. Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity

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