Affiliation:
1. Department of Pediatrics, Division of Hematology‐Oncology Baylor College of Medicine Houston TX USA
Abstract
Removal of polyploid cells is essential to preventing cancer and restricting tumor growth. A new study published in The EMBO Journal shows assembly of the NEMO‐PIDDosome on extra centrioles. Activation of this protein complex leads to NF‐κB activation that, in turn, induces NK cell‐mediated cell clearance.
Publisher
Springer Science and Business Media LLC
Subject
General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience