Substrate recruitment of γ‐secretase and mechanism of clinical presenilin mutations revealed by photoaffinity mapping-Reference-Cited by-同舟云学术

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Substrate recruitment of γ‐secretase and mechanism of clinical presenilin mutations revealed by photoaffinity mapping

Published:2016-05-24 Issue:15 Volume:35 Page:1628-1643
ISSN:0261-4189
Container-title:The EMBO Journal
language:en
Short-container-title:EMBO J

Author:

Fukumori Akio¹²,Steiner Harald¹²^ORCID

Affiliation:

1. Biomedical Center (BMC) Metabolic Biochemistry Ludwig‐Maximilians‐University Munich Munich Germany

2. German Center for Neurodegenerative Diseases (DZNE) Munich Germany

Funder

Deutsche Forschungsgemeinschaft

Publisher

EMBO

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

Link

https://onlinelibrary.wiley.com/doi/pdf/10.15252/embj.201694151

Reference78 articles.

1. Allosteric regulation of rhomboid intramembrane proteolysis

2. Sampling the conformational space of the catalytic subunit of human γ-secretase

3. An atomic structure of human γ-secretase

4. Functional and Topological Analysis of Pen-2, the Fourth Subunit of the γ-Secretase Complex

5. Nicastrin functions to sterically hinder γ-secretase–substrate interactions driven by substrate transmembrane domain

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