Cryo‐EM structure of the human NKCC1 transporter reveals mechanisms of ion coupling and specificity

Author:

Neumann Caroline12ORCID,Rosenbæk Lena Lindtoft3ORCID,Flygaard Rasmus Kock12ORCID,Habeck Michael12ORCID,Karlsen Jesper Lykkegaard2,Wang Yong45ORCID,Lindorff‐Larsen Kresten4ORCID,Gad Hans Henrik2ORCID,Hartmann Rune2ORCID,Lyons Joseph Anthony126ORCID,Fenton Robert A3ORCID,Nissen Poul12ORCID

Affiliation:

1. Danish Research Institute of Translational Neuroscience—DANDRITE Nordic EMBL Partnership for Molecular Medicine Aarhus Denmark

2. Department of Molecular Biology and Genetics Aarhus University Aarhus Denmark

3. Department of Biomedicine Aarhus University Aarhus Denmark

4. Linderstrøm‐Lang Centre for Protein Science, Department of Biology University of Copenhagen Copenhagen Denmark

5. Shanghai Institute for Advanced Study, Institute of Quantitative Biology, College of Life Sciences Zhejiang University Hangzhou China

6. Interdisciplinary Nanoscience Center (iNANO) Aarhus University Aarhus Denmark

Funder

Fondation Leducq

Lundbeckfonden

Novo Nordisk Fonden

Carlsbergfondet

Publisher

EMBO

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

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