A Notch positive feedback in the intestinal stem cell niche is essential for stem cell self‐renewal

Author:

Chen Kai‐Yuan12ORCID,Srinivasan Tara3,Tung Kuei‐Ling4,Belmonte Julio M5ORCID,Wang Lihua24,Murthy Preetish Kadur Lakshminarasimha6,Choi Jiahn2,Rakhilin Nikolai12,King Sarah3,Varanko Anastasia Kristine4,Witherspoon Mavee6,Nishimura Nozomi3ORCID,Glazier James A5,Lipkin Steven M7,Bu Pengcheng28ORCID,Shen Xiling123ORCID

Affiliation:

1. School of Electrical and Computer Engineering Cornell University Ithaca NY USA

2. Department of Biomedical Engineering Duke University Durham NC USA

3. Department of Biomedical Engineering Cornell University Ithaca NY USA

4. Department of Biological and Environmental Engineering Cornell University Ithaca NY USA

5. Biocomplexity Institute and Department of Physics Indiana University Bloomington IN USA

6. School of Mechanical Aerospace Engineering Cornell University Ithaca NY USA

7. Departments of Medicine, Genetic Medicine and Surgery Weill Cornell Medical College New York NY USA

8. Key Laboratory of RNA Biology Key Laboratory of Protein and Peptide Pharmaceutical Institute of Biophysics Chinese Academy of Sciences Beijing China

Funder

U.S. Department of Defense

National Institute of General Medical Sciences

National Science Foundation

Publisher

EMBO

Subject

Applied Mathematics,Computational Theory and Mathematics,General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Information Systems

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