Affiliation:
1. Genome Biology Unit European Molecular Biology Laboratory (EMBL) Heidelberg Germany
2. Department of Genetics Stanford University School of Medicine Stanford CA USA
3. Stanford Genome Technology Center Palo Alto CA USA
Abstract
Microscopy and fluorescence‐activated cell sorting (FACS) are two of the most important tools for single‐cell phenotyping in basic and biomedical research. Microscopy provides high‐resolution snapshots of cell morphology and the inner workings of cells, while FACS isolates thousands of cells per second using simple parameters, such as the intensity of fluorescent protein labels. Recent technologies are now combining both methods to enable the fast isolation of cells with microscopic phenotypes of interest, thereby bridging a long‐standing gap in the life sciences. In this Commentary, we discuss the technical advancements made by image‐enabled cell sorting and highlight novel experimental strategies in functional genomics and single‐cell research.
Funder
European Research Council
HORIZON EUROPE Marie Sklodowska-Curie Actions
Publisher
Springer Science and Business Media LLC
Subject
Applied Mathematics,Computational Theory and Mathematics,General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Information Systems
Cited by
4 articles.
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