Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation

Author:

Kelmer Sacramento Erika1ORCID,Kirkpatrick Joanna M1,Mazzetto Mariateresa12,Baumgart Mario1,Bartolome Aleksandar1,Di Sanzo Simone1,Caterino Cinzia12,Sanguanini Michele3ORCID,Papaevgeniou Nikoletta4,Lefaki Maria4,Childs Dorothee5,Bagnoli Sara2,Terzibasi Tozzini Eva2,Di Fraia Domenico1,Romanov Natalie5,Sudmant Peter H6ORCID,Huber Wolfgang5,Chondrogianni Niki4,Vendruscolo Michele3ORCID,Cellerino Alessandro12ORCID,Ori Alessandro1ORCID

Affiliation:

1. Leibniz Institute on Aging‐Fritz Lipmann Institute (FLI) Jena Germany

2. Bio@SNS Scuola Normale Superiore Pisa Italy

3. Centre for Misfolding Diseases Department of Chemistry University of Cambridge Cambridge UK

4. Institute of Chemical Biology National Hellenic Research Foundation Athens Greece

5. European Molecular Biology Laboratory Heidelberg Germany

6. University of California Berkeley Berkeley CA USA

Funder

Else Kröner-Fresenius-Stiftung

Deutsches Zentrum für Herz-Kreislaufforschung

Deutsche Forschungsgemeinschaft

European Union and Greek National Funds

Empirikeion Foundation

Publisher

EMBO

Subject

Applied Mathematics,Computational Theory and Mathematics,General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Information Systems

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