Stress‐sensitive dynamics of miRNAs and Elba1 in Drosophila embryogenesis

Author:

Örkenby Lovisa1ORCID,Skog Signe1ORCID,Ekman Helen1ORCID,Gozzo Alessandro1ORCID,Kugelberg Unn1,Ramesh Rashmi1ORCID,Magadi Srivathsa2ORCID,Zambanini Gianluca3ORCID,Nordin Anna3ORCID,Cantú Claudio3ORCID,Nätt Daniel1ORCID,Öst Anita1ORCID

Affiliation:

1. Department of Biomedical and Clinical Sciences Linköping University Linköping Sweden

2. Division of Neurobiology (NEURO) Linköping University Linköping Sweden

3. Division of Molecular Medicine and Virology (MMV) Linköping University Linköping Sweden

Abstract

AbstractEarly‐life stress can result in life‐long effects that impact adult health and disease risk, but little is known about how such programming is established and maintained. Here, we show that such epigenetic memories can be initiated in the Drosophila embryo before the major wave of zygotic transcription, and higher‐order chromatin structures are established. An early short heat shock results in elevated levels of maternal miRNA and reduced levels of a subgroup of zygotic genes in stage 5 embryos. Using a Dicer‐1 mutant, we show that the stress‐induced decrease in one of these genes, the insulator‐binding factor Elba1, is dependent on functional miRNA biogenesis. Reduction in Elba1 correlates with the upregulation of early developmental genes and promotes a sustained weakening of heterochromatin in the adult fly as indicated by an increased expression of the PEV wm4h reporter. We propose that maternal miRNAs, retained in response to an early embryonic heat shock, shape the subsequent de novo heterochromatin establishment that occurs during early development via direct or indirect regulation of some of the earliest expressed genes, including Elba1.

Funder

Knut och Alice Wallenbergs Stiftelse

Ragnar Söderbergs stiftelse

Vetenskapsrådet

Publisher

Springer Science and Business Media LLC

Subject

Applied Mathematics,Computational Theory and Mathematics,General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Information Systems

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