The Antibiotics Susceptibility Profile of Acinetobacter spp Isolated from Clinical Specimens in University Teaching Hospital

Abstract

The genus Acinetobacter currently contains 34 species, the vast majority of which are not regularly implicated in causing infection. However, Carbapenems have long been thought of as the agents of choice for serious Acinetobacter baumannii infections. The objective of this study is to determine the Antibiotics susceptibility profile of Acinetobacter spp Isolated from clinical specimen University of Ilorin Teaching Hospital, Ilorin. The descriptive cross-sectional study is conducted in UITH located in North Central Nigeria. 10 strains of Acinetobacter spp. were isolated from clinical samples between February to July 2018. The isolated strains were identified using standard microbiological methods, API20NE. Antimicrobial susceptibility was performed using the Modified Kirby Bauer method with the organism tested against Amoxicillin, Amoxicillin-Clavulanate, Ceftriaxone, Cefixime, Cefuroxime, Streptomycin, Perfloxacin, Gentamicin, Imipenem, Nitrofurantoin. Most of the antibiotics used in this study are mostly multi-drug resistant. Amoxicillin (100%), Cefixime, Amoxicillin Clavulanate (100%), Cefuroxime (100%), Gentamicin (100%), Nitrofurantoin (100%), Ceftriaxone (100%) but 80% are susceptible to Imipenem. Carbapenems are the best antibiotic treatment option for infections arising from these organisms although a coordinated rational usage is desired along with a functional antibiotic prescription policy to avoid treatment failures. Continuous monitoring of resistance patterns is necessary to strengthen infection control policies.