Abstract
Objective: Genetic variations have been identified in specific regions of the Vitamin D receptor (VDR) gene and many studies were
investigating whether these variations are associated with malignancy. Studies in the VDR on children are scarce. In this study, we
aimed to investigate the VDR gene polymorphisms in pediatric patients with the diagnosis of leukemia and lymphoma.
Patients and Methods: Of the 99 participants included in this cross-sectional study, 59 were control, 40 were patients. Fok-I, Bsm-I
and Taq-I polymorphism of the VDR gene were investigated in both groups.
Results: While no significant difference was found in the genotype distribution of the three polymorphisms between the patient and
control groups, significant results were obtained in Bsm-I and Taq-I allele frequencies (Odds ratio=0.489; CI95%=0.275-0.871 and
0.519; CI95%=0.280-0.964) (p
Reference21 articles.
1. Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer Statistics,
2021. CA Cancer J Clin 2021;71:7-33. doi: 10.3322/caac.21654.
2. Pearce SH, Cheetham TD. Diagnosis and management of
vitamin D deficiency. BMJ 2010;340:b5664. doi:10.1136/bmj.
b5664
3. Deeb KK, Trump DL, Johnson CS. Vitamin D signaling
pathways in cancer: potential for anticancer therapeutics. Nat
Rev Cancer 2007; 7:684-700. doi:10.1038/nrc2196
4. Köstner K, Denzer N, Muller CSL, Klein R, Tilgen W,
Reichranth J. The Relevance of Vitamin D Receptor (VDR)
gene polymorphisms for cancer: A review of the literature.
Anticancer Res 2009; 29:3511-36. PMID: 19667145.
5. Raimondi S, Harriet Johansson H, Patrick Maisonneuve P,
Gandini S. Review and meta-analysis on vitamin D receptor
polymorphisms and cancer risk. Carcinogenesis 2009;
30:1170-80. doi: 10.1093/carcin/bgp103.