Abstract
The involvement of the Signal peptide-complement components of C1r/C1s, the sea urchin Uegf and Bone Morphogenetic Protein
(CUB) domain-Epidermal Growth Factor (EGF)-related (SCUBE) gene in human diseases has been progressively apparent. The SCUBE1
is detectable in platelet-aggregation diseases. The SCUBE2 is reported to have a better cancer survival prognosis. However, SCUBE3 is
detected in bone-related diseases. SCUBE gene interacts with Hedgehog (Hh) signaling pathway and epidermal growth factor receptor
(EGFR), which has a wide range of biological functions such as cell proliferation, apoptosis, differentiation, and activation of platelet
activity.
The current review is a systematic review performed using SCOPUS, Cochrane, and Pubmed/Medline according to The Preferred
Reporting Items for Systematic Reviews and Meta-Analysis Protocol (PRISMA-P) guidelines. This review discusses the entanglement
of the SCUBE gene’s potential role in human diseases. Examining the role of the SCUBE family sheds new light on platelet aggregationrelated
diseases, cancer prognosis, and their pathogenesis.