Affiliation:
1. Department of Physiology, Faculty of Medicine, University of Debrecen, Debrecen H-4002, Hungary
2. Department of Biochemistry, Faculty of Medicine, University of Szeged, Szeged H-6720, Hungary
Abstract
Oxidative stress is characterized by an imbalance between prooxidant and antioxidant species, leading to macromolecular damage and disruption of redox signaling and cellular control. It is a hallmark of various diseases including metabolic syndrome, chronic fatigue syndrome, neurodegenerative, cardiovascular, inflammatory, and age-related diseases. Several mitochondrial defects have been considered to contribute to the development of oxidative stress and known as the major mediators of the aging process and subsequent age-associated diseases. Thus, mitochondrial-targeted antioxidants should prevent or slow down these processes and prolong longevity. This is the reason why antioxidant treatments are extensively studied and newer and newer compounds with such an effect appear. Astaxanthin, a xanthophyll carotenoid, is the most abundant carotenoid in marine organisms and is one of the most powerful natural compounds with remarkable antioxidant activity. Here, we summarize its antioxidant targets, effects, and benefits in diseases and with aging.
Funder
New National Excellence Program of the Ministry for Innovation and Technology Sciences
Subject
Cell Biology,Ageing,General Medicine,Biochemistry
Cited by
115 articles.
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