Adaptive Immunity, Inflammation, and Cardiovascular Complications in Type 1 and Type 2 Diabetes Mellitus-Reference-Cited by-同舟云学术

Adaptive Immunity, Inflammation, and Cardiovascular Complications in Type 1 and Type 2 Diabetes Mellitus

Published:2013 Issue: Volume:2013 Page:1-11
ISSN:2314-6745
Container-title:Journal of Diabetes Research
language:en
Short-container-title:Journal of Diabetes Research

Author:

Pedicino Daniela¹,Liuzzo Giovanna¹,Trotta Francesco¹,Giglio Ada Francesca¹,Giubilato Simona¹,Martini Francesca²,Zaccardi Francesco²,Scavone Giuseppe²,Previtero Marco¹,Massaro Gianluca¹,Cialdella Pio¹,Cardillo Maria Teresa¹,Pitocco Dario²,Ghirlanda Giovanni²,Crea Filippo¹

Affiliation:

1. Institute of Cardiology, Catholic University, Largo A. Gemelli, 8-00168 Rome, Italy

2. Diabetes Care Unit, Internal Medicine, Catholic University, Largo A. Gemelli, 8-00168 Rome, Italy

Abstract

Diabetes mellitus (DM) is a pandemics that affects more than 170 million people worldwide, associated with increased mortality and morbidity due to coronary artery disease (CAD). In type 1 (T1) DM, the main pathogenic mechanism seems to be the destruction of pancreaticβ-cells mediated by autoreactive T-cells resulting in chronic insulitis, while in type 2 (T2) DM primary insulin resistance, rather than defective insulin production due toβ-cell destruction, seems to be the triggering alteration. In our study, we investigated the role of systemic inflammation and T-cell subsets in T1- and T2DM and the possible mechanisms underlying the increased cardiovascular risk associated with these diseases.

Publisher

Hindawi Limited

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism

Link

http://downloads.hindawi.com/journals/jdr/2013/184258.pdf

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