Electroacupuncture Pretreatment Exhibits Lung Protective and Anti-Inflammation Effects in Lipopolysaccharide-Induced Acute Lung Injury via SIRT1-Dependent Pathways

Author:

Luo Dan12ORCID,Liu Li3,Zhang Hai-ming24,Zhou Yu-dian2,Zhou Min-feng5,Li Jin-xiao5,Yu Zhao-min6,Tang Qian2,Yang Shu-rui2,Chen Rui5ORCID,Liang Feng-xia2ORCID

Affiliation:

1. Department of Respiratory, Wuhan No. 1 Hospital, Wuhan 430022, China

2. Department of Acupuncture and Moxibustion, Hubei University of Traditional Chinese Medicine, Wuhan 430061, China

3. Department of Pathology, Wuhan No. 1 Hospital, Wuhan 430022, China

4. Department of Oncology, Integrated Traditional Chinese and Western Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China

5. Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China

6. Department of Oncology, Hubei Province Hospital of Integrated Traditional Chinese and Western Medicine, Wuhan 430015, China

Abstract

To investigate the effect of electroacupuncture (EA) on acute lung injury (ALI), a lipopolysaccharide (LPS) induced ALI mouse model was used in this study. Before receiving intratracheal LPS instillation, mice were given EA at ST36 for 7 days as a long-term treatment or one time as a short-term treatment. Lung histopathological examination, lung injury scores, lung wet/dry (W/D) ratio, and inflammatory cytokines included proinflammation factors such as TNF-α, IL-1β, and IL-6 and anti-inflammation factors such as IL-4 and IL-10 in serum and bronchoalveolar lavage fluid (BALF) were detected at the end of experiment. The results show that EA pretreatment ameliorated the lung damage and inflammatory response by LPS. In addition, we found that SIRT1 and its deacetylation of NF-κB were promoted after EA pretreatment in lung tissues. Meanwhile, the expression of angiotensin-converting enzyme 2 (ACE2) is also enhanced by EA pretreatment. Thus, the present findings suggest that EA could be a potential therapy of ALI.

Funder

National Natural Science Foundation of China

Publisher

Hindawi Limited

Subject

Complementary and alternative medicine

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