Affiliation:
1. Department of Respiratory Medicine, The Second Hospital of Jilin University, Changchun, Jilin Province 130041, China
Abstract
Background.Overexpression of the MUC5B protein is associated with idiopathic pulmonary fibrosis (IPF), but little information is available regarding the pathogenic effects and regulatory mechanisms of overexpressed MUC5B in IPF.Main Body.The overexpression of MUC5B in terminal bronchi and honeycomb cysts produces mucosal host defensive dysfunction in the distal airway which may play an important role in the development of IPF. This review addresses the possible association of overexpression ofMUC5B, withMUC5Bpromoter polymorphism,MUC5Bgene epigenetic changes, effects of some transcriptional factors, and inflammatory mediators in IPF. In addition, the associated signaling pathways which may influence the expression ofMUC5Bare also discussed.Conclusion.This work has important implications for further exploration of the mechanisms of overexpression of MUC5B in IPF, and future personalized treatment.
Funder
Department of Finance of Jilin Province
Subject
General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine
Cited by
30 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献