An Overview of Lipid Metabolism and Nonalcoholic Fatty Liver Disease

Author:

Pei Ke1ORCID,Gui Ting234,Kan Dongfang234,Feng Huichao5,Jin Yanqiang6,Yang Ying234,Zhang Qian7,Du Ziwei8,Gai Zhibo2349ORCID,Wu Jibiao1ORCID,Li Yunlun710ORCID

Affiliation:

1. College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China

2. Experimental Center, Shandong University of Traditional Chinese Medicine, Jinan, China

3. Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Jinan, China

4. Shandong Provincial Key Laboratory of Traditional Chinese Medicine for Basic research, Shandong University of Traditional Chinese Medicine, Jinan, China

5. Acupuncture and Massage College, Shandong University of Traditional Chinese Medicine, Jinan, China

6. Traditional Chinese Medicine Department, Tai’an Maternal and Child Health Hospital, Tai’an, China

7. First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China

8. Institute of Rehabilitation, Shandong University of Traditional Chinese Medicine, Jinan, China

9. Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, 8006 Zurich, Switzerland

10. The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China

Abstract

The occurrence of nonalcoholic fatty liver disease (NAFLD) is associated with major abnormalities of hepatic lipid metabolism. We propose that lipid abnormalities directly or indirectly contribute to NAFLD, especially fatty acid accumulation, arachidonic acid metabolic disturbance, and ceramide overload. The effects of lipid intake and accumulation on NAFLD and NAFLD treatment are explained with theoretical and experimental details. Overall, these findings provide further understanding of lipid metabolism in NAFLD and may lead to novel therapies.

Funder

National Natural Science Foundation of China

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

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