Clinicopathological Features and Prognostic-Related Risk Factors of Gastric Signet Ring Cell Carcinoma: A Meta-Analysis

Abstract

Background. Gastric signet ring cell carcinoma (SRCC) has shown a growth growing trend worldwide, but its clinicopathological features and prognostic-related risk factors have not been systematically studied. This systematic review was devoted to this. Method. PubMed, Embase, Cochrane Library, and Web of Science databases were retrieved, and retrospective cohort studies comparing clinicopathological features and related risk factors in SRCC patients were included. Results. In SRCC patient population, males were more than females (male,$\text{OR}=1.38$, 95% CI: 1.20-1.60); N3 patients were more than N0-2 patients (N0-2,$\text{OR}=3.19$, 95% CI: 1.98-5.15); M1 patients were more than M0 patients (M0,$\text{OR}=3.30$, 95% CI: 1.88-5.80); patients with$\text{tumor}>5$ cm were more than those with tumor ($\le 5$ cm,$\text{OR}=7.36$, 95% CI: 1.33-40.60). Patients with$\text{age}<60$years ($\text{age}\ge 60$years,$\text{OR}=1.03$, 95% CI: 1.01-1.05), lymphatic vessel invasion (no,$\text{OR}=1.74$, 95% CI: 1.03-2.45), T2 (T1,$\text{OR}=1.17$, 95% CI: 1.07-1.28) and T4 (T1,$\text{OR}=2.55$, 95% CI: 2.30-2.81) stages, and N1 (N0,$\text{OR}=1.73$, 95% CI: 1.08-2.38), N2 (N0,$\text{OR}=2.24$, 95% CI: 1.12-3.36), and N3 (N0,$\text{OR}=3.45$, 95% CI: 1.58-5.32) stages had higher hazard ratio (HR). Conclusion. SRCC may occur frequently in male. Age, lymphatic vessel invasion, TN, and M stage may be risk factors for poor prognoses of SRCC patients.