Reversal of a Suspected Paradoxical Reaction to Zopiclone with Flumazenil

Author:

Jordahn Zarah1ORCID,Andersen Cheme2,Roust Aaberg Anne Marie3,Christian Pott Frank3ORCID

Affiliation:

1. Department of Anaesthesiology, Rigshospitalet, Glostrup Matriklen, Copenhagen, Denmark

2. Department of Anaesthesiology, Copenhagen University Hospital, Hvidovre, Denmark

3. Department of Anaesthesia and Intensive Care, Bispebjerg Hospital, Copenhagen, Denmark

Abstract

We describe the care for an elderly woman who was admitted to the intensive care unit (ICU) to receive noninvasive ventilation for acute exacerbation of chronic obstructive pulmonary disease. After administration of the sleeping pill zopiclone, a nonbenzodiazepine receptor agonist (NBRA), the patient became agitated and was confused, a possible paradoxical reaction to benzodiazepines. These symptoms were immediately resolved after treatment with flumazenil, usually used to reverse the adverse effects of benzodiazepines or NBRAs and to reverse paradoxical reactions to benzodiazepines. This case indicates that zopiclone induced behavioral changes resembling a paradoxical reaction to benzodiazepines and these symptoms may be treated with flumazenil.

Publisher

Hindawi Limited

Subject

Critical Care and Intensive Care Medicine

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