Effect of Glucocorticoids on Ultrastructure of Myocardial Muscle in the Course of Experimentally Induced Acute Myocardial Ischemia-Reference-Cited by-同舟云学术

Effect of Glucocorticoids on Ultrastructure of Myocardial Muscle in the Course of Experimentally Induced Acute Myocardial Ischemia

Published:2017 Issue: Volume:2017 Page:1-5
ISSN:2314-6133
Container-title:BioMed Research International
language:en
Short-container-title:BioMed Research International

Author:

Kuropka Piotr¹^ORCID,Dobrzyński Maciej²^ORCID,Gamian Andrzej³,Gostomska-Pampuch Kinga⁴,Kuryszko Jan¹,Całkosiński Ireneusz⁵

Affiliation:

1. Department of Histology and Embriology, Wroclaw University of Environmental and Life Sciences, Norwida 31, 50-375 Wrocław, Poland

2. Department of Conservative Dentistry and Pedodontics, Wroclaw Medical University, Krakowska 26, 50-425 Wrocław, Poland

3. Department of Medical Biochemistry, Wroclaw Medical University, Chałubińskiego 10, 50-368 Wrocław, Poland

4. Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, 53-114 Wroclaw, Poland

5. Laboratory of Neurotoxicology and Environmental Diagnostics, Wroclaw Medical University, Bartla 5, 51-618 Wroclaw, Poland

Abstract

The search for effective methods of myocardial cytoprotection against ischemia is the most significant issue in modern cardiology and cardiac surgery. Glucocorticoids are deemed very strong modulators of inflammatory response and thus can potentially protect heart muscle from postreperfusion injury and myocardial ischemia during cardiac surgery. Ultrastructural examination of the left ventricle heart samples revealed that the intravenous application of dexamethasone and hydrocortisone proved to exert cytoprotective effect on cardiomyocytes during experimentally induced acute ischemia in rats.

Funder

Wroclaw Centre of Biotechnology

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://downloads.hindawi.com/journals/bmri/2017/2108497.pdf

Reference22 articles.

1. Mitochondrial Metabolism in Aging Heart

2. Cardiopulmonary bypass induced inflammation: pathophysiology and treatment. An update

3. Limiting myocardial cell injury during cardiopulmonary bypass: Are steroids the answer? *