Simvastatin in the Treatment of Colorectal Cancer: A Review-Reference-Cited by-同舟云学术

Simvastatin in the Treatment of Colorectal Cancer: A Review

Published:2022-07-14 Issue: Volume:2022 Page:1-6
ISSN:1741-4288
Container-title:Evidence-Based Complementary and Alternative Medicine
language:en
Short-container-title:Evidence-Based Complementary and Alternative Medicine

Author:

Zang Hongliang¹,Yang Wei¹^ORCID,Tian Xiaofeng¹^ORCID

Affiliation:

1. Department of Hepatopancreatobiliary Surgery, China-Japan Union Hospital of Jilin University, Changchun, China

Abstract

Drug repositioning and drug reuse are the heated topics in the field of oncology in recent years. These two concepts refer to seeking effective drugs for cancer that are not originally intended to treat cancer. The survival benefits are then analyzed by combining the re-positioned drugs with conventional cancer treatment methods. Simvastatin is a clinically commonly used hyperlipidemia drug and exerts the effect of preventing cardiovascular diseases. Recent studies have found that simvastatin has great potential in the treatment of colorectal cancer, and a large number of clinical studies have used simvastatin as an adjuvant drug to help treat metastatic colorectal cancer.

Publisher

Hindawi Limited

Subject

Complementary and alternative medicine

Link

http://downloads.hindawi.com/journals/ecam/2022/3827933.pdf

Reference52 articles.

1. Predictive pharmacogenetic biomarkers for breast cancer recurrence prevention by simvastatin

2. Niosomal delivery of simvastatin to MDA-MB-231 cancer cells

3. Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors

4. Comprehensive review of targeted therapy for colorectal cancer

5. Angiogenesis in cancer

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Compound 225# inhibits the proliferation of human colorectal cancer cells by promoting cell cycle arrest and apoptosis induction;Oncology Reports;2024-04-02

2. In-silico, Synthesis, Characterization, and In-vitro Studies on Benzylidene-based 2-chloroquinolin Derivatives as Free Radical Scavengers in Parkinson’s Disease;Drug Research;2024-02

3. Retracted: Simvastatin in the Treatment of Colorectal Cancer: A Review;Evidence-Based Complementary and Alternative Medicine;2023-12-06

4. Targeted Therapies in Colorectal Cancer: Recent Advances in Biomarkers, Landmark Trials, and Future Perspectives;Cancers;2023-06-01

5. Drug repurposing and molecular mechanisms of the antihypertensive drug candesartan as a TMEM16A channel inhibitor;International Journal of Biological Macromolecules;2023-04