Anti-Inflammatory and Antioxidant Effects of the Indole-Derived N-Salicyloyltryptamine on Peritonitis and Joint Disability Induced by Carrageenan in Rodents

Author:

Sousa-Neto B. P.1ORCID,Cunha F. V. M.1ORCID,Nunes Daniel Barbosa1ORCID,Gomes B. S.1ORCID,Amorim Layane Valeria1ORCID,Lopes Everton Moraes1ORCID,Gutierrez S. J. C.2ORCID,Almeida F. R. C.13ORCID,Arcanjo D. D. R.14ORCID,Souza M. F. V.5ORCID,Oliveira F. A.13ORCID

Affiliation:

1. Medicinal Plants Research Center, Federal University of Piaui, Av. Universitária s/n, Campus Ministro Petrônio Portella, SG-15, Ininga, 64049-550 Teresina, PI, Brazil

2. Faculty of Pharmacy, Federal University of Piauí, Av. Universitária s/n, Campus Ministro Petrônio Portella, Ininga, 64049-550 Teresina, PI, Brazil

3. Department of Biochemistry and Pharmacology, Federal University of Piauí, Av. Universitário s/n, Campus Ministro Petrônio Portella, SG-08, Ininga, 64049-550 Teresina, PI, Brazil

4. Department of Biophysics and Physiology, Federal University of Piauí, Av. Universitária s/n, Campus Ministro Petrônio Portella, Ininga, 64049-550 Teresina, PI, Brazil

5. Federal University of Paraíba, Coordinator of the Graduate Program in Development and Technological Innovation of Drugs. (Association UFRN/UFPB/UFRPE/UFC), 64049-550 Teresina, PI, Brazil

Abstract

Purpose. To investigate the anti-inflammatory and antioxidant activities of N-salicyloyltryptamine (NST) in experimental models of carrageenan (Cg)-induced peritonitis in mice, and evaluation of the effects of NST on Cg-induced joint disability in rats. Methods. Female Swiss mice were submitted to Cg-induced peritonitis in mice or Cg-induced joint disability in rats after intraperitoneal injection of NST (100 or 200 mg/kg). Total leukocyte count, total protein concentration, myeloperoxidase (MPO) and catalase (CAT) activities, and nitrite ( NO 2 ) and thiobarbituric acid reactive species (TBARS) levels were determined. Results. NST significantly decrease the migration of leukocytes to peritoneal exudate. Cg induces inflammatory responses mediated by expression of reactive oxygen species (ROS). The results further showed that NST significantly decreased MPO and CAT activities, as well as reduced NO 2 and TBARS levels, compared with the vehicle group. Animals treated with NST significantly reduced paw elevation time (PET) on the first hour after induction of joint injury, and this effect was sustained throughout the analysis. Conclusion. NST presented anti-inflammatory and antioxidant effects in experimental models of carrageenan-induced peritonitis and joint disability in mice and rats, respectively, which may be related to the modulation of neutrophils migration as well as the involvement of antioxidant mechanisms.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

Hindawi Limited

Subject

Complementary and alternative medicine

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