Regulation of Serum Response Factor and Adiponectin by PPARγAgonist Docosahexaenoic Acid

Author:

Johnson Clayton12,Williams Roslyn3,Wei Jeanne Y.1,Ranganathan Gouri13

Affiliation:

1. Donald W. Reynolds Institute on Aging University of Arkansas for Medical Sciences, 4301 West Markham Street, Slot no. 748, Little Rock, AR 72205, USA

2. Biology Department, University of Arkansas at Pine Bluff, Pine Bluff, AR 71601, USA

3. Central Arkansas Veterans Healthcare System, 4300 West 7th Street, Little Rock, AR 72205, USA

Abstract

Recent studies indicate that significant health benefits involving the regulation of signaling proteins result from the consumption of omega-3 polyunsaturated fatty acids (ω-3 PUFAs). Serum response factor (SRF) is involved in transcriptional regulation of muscle growth and differentiation. SRF levels are increased in the aging heart muscle. It has not been examined whether SRF is made by adipocytes and whether SRF secretion by adipocytes is modulated by PPARγagonist DHA. Adiponectin is made exclusively by adipocytes. We and others have previously reported that PUFAs such as DHA increase adiponectin levels and secretion in adipocytes. Here we show that DHA downregulates SRF with a simultaneous upregulation of adiponectin and that both these responses are reversible by PPARγantagonist. Furthermore, there appears to be a direct relationship between DHA exposure and increased levels of membrane-associated high-density adiponectin, as well as lower levels of membrane-associated SRF. Thus, we find that the levels of SRF and adiponectin are inversely related in response to treatment with PPARγagonist DHA. Decreased levels of SRF along with increase in membrane-associated adiponectin could in part mediate the health benefits of DHA.

Funder

National Institutes of Health

Publisher

Hindawi Limited

Subject

Biochemistry

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