Clinical Efficacy of Assisted Reproductive Technology Combined with Progesterone Capsules in the Treatment of Infertility Caused by Diminished Ovarian Reserve and Its Influence on Serum FSH, E2, and LH Levels of Patients

Abstract

Objective. To explore the clinical efficacy of assisted reproductive technology (ART) combined with progesterone capsules in the treatment of infertility caused by the diminished ovarian reserve (DOR) and its influence on serum FSH, E2, and LH levels of patients. Methods. In the manner of retrospective study, the data of 120 patients with infertility caused by DOR admitted to our hospital (February 2019–February 2020) were retrospectively analyzed, and the patients were equally divided into the experimental group and the control group according to the order of admission. All patients underwent in vitro fertilization and embryo transfer (IVF-ET), and the experimental group was received progesterone capsules at the same time. Ovarian-related indexes, follicular development, serum hormone levels, and pregnancy outcomes were compared between both groups. Results. After treatment, compared with the control group, ovarian-related indexes and follicular development in the experimental group were conspicuously better $\left(P<0.001\right)$ . In the experimental group, the FSH level was (5.99 ± 1.20) U/L, the E2 level was (540.12 ± 3.54) ng/L, and the LH level was (3.10 ± 0.35) U/L after treatment, which was significantly better than those of the control group $\left(P<0.001\right)$ . After treatment, compared with the control group, the clinical pregnancy rate in the experimental group was conspicuously higher $\left(P<0.05\right)$ , and the abortion rate in the experimental group was conspicuously lower $\left(P<0.05\right)$ . No obvious difference was observed in multiple births rate between the two groups $\left(P>0.05\right)$ . Conclusion. ART combined with progesterone capsules can improve serum hormone levels, ovarian function, follicular development, and clinical pregnancy rate for patients with infertility caused by DOR, which should be applied in practice.