Phenolic Compound Analysis and Pharmacological Screening of Vitex agnus-castus Functional Parts

Author:

Berrani Assia1,Marmouzi Ilias2ORCID,Bouyahya Abdelhakim3ORCID,Kharbach Mourad2,El Hamdani Maha4,El Jemli Meryem5,Lrhorfi Aicha1,Zouarhi Meryem6,Faouzi My El Abbes2,Bengueddour Rachid1

Affiliation:

1. Laboratory of Biochemistry, Biotechnology, Health and the Environment, Department of Biology, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco

2. Université Mohammed V de Rabat, Faculté de Médecine et de Pharmacie, Laboratoire de Pharmacologie et Toxicologie, Rabat, Morocco

3. Laboratory of Human Pathologies Biology, Faculty of Sciences and Genomic Center of Human Pathologies, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Morocco

4. Faculté des Sciences, Université Ibn Tofail, Rabat, Morocco

5. Faculty of Pharmacy, Mohammed VI University of Health Sciences (UM6SS), Casablanca, Morocco

6. Laboratory of Electrochemistry and Materials Environment (LMEE), Department of Chemistry, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco

Abstract

Vitex agnus-castus is a medicinal plant of the Verbenaceae family, widely used in traditional medicine. This study is aimed at investigating the functional variability of phenolic compounds in different parts (leaves, stems, flowers, roots, and seeds) of Vitex agnus-castus methanolic extracts and at assessing their in vitro antidiabetic, antioxidant, and antibacterial activities. The results of HPLC-DAD-QTOF-MS indicated the presence of 25 phenolic compounds with a remarkable variability between plant parts; high levels were registered in chlorogenic, vanillic, 3,4-dihydroxybenzoic, and 3-hydroxybenzoic acids; hesperidin; and luteolin. V. agnus castus fruits and stems presented higher antioxidant activities. The extracts inhibited the growth of five pathogenic bacteria with MIC values documented between 7.81 and 31.25 mg/mL. In vitro antihyperglycemic effect revealed higher effect in flowers (2921.84 μg/mL) and seeds (2992.75 μg/mL) against α-glucosidase and of leaves (2156.80 μg/mL) and roots (2357.30 μg/mL) against α-amylase. The findings of this showed that V. agnus castus is a promising source for antidiabetic bioactive compounds. However, further investigations regarding the evaluation of in vivo antidiabetic effects of these compounds are needed.

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

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