Affiliation:
1. Department of Obstetrics and Gynecology, People’s Hospital of Chongqing Banan District, Chongqing 401320, China
2. Department of Obstetrics and Gynecology, Liaocheng People’s Hospital and LiaochengClinical School of Shandong First Medical University, Liaocheng, Shandong 252000, China
3. School of Clinical Medicine, Chongqing Medical and Pharmaceutical College; Chongqing Engineering Research Center of Pharmaceutical Sciences, Shapingba District, Chongqing, 401331, China
Abstract
Gestational diabetes mellitus (GDM) is a major public health issue, and the aim of the present study was to identify the factors associated with GDM. Databases were searched for observational studies until August 20, 2020. Pooled odds ratios (ORs) were calculated using fixed- or random-effects models. 103 studies involving 1,826,454 pregnant women were identified. Results indicated that
years (OR: 2.466, 95% CI: (2.121, 2.866)), prepregnancy overweight or obese (OR: 2.637, 95% CI: (1.561, 4.453)), family history of diabetes (FHD) (OR: 2.326, 95% CI: (1.904, 2.843)), history of GDM (OR: 21.137, 95% CI: (8.785, 50.858)), macrosomia (OR: 2.539, 95% CI: (1.612, 4.000)), stillbirth (OR: 2.341, 95% CI: (1.435, 3.819)), premature delivery (OR: 3.013, 95% CI: (1.569, 5.787)), and pregestational smoking (OR: 2.322, 95% CI: (1.359, 3.967)) increased the risk of GDM with all
, whereas history of congenital anomaly and abortion, and HIV status showed no correlation with GDM (
). Being primigravida (OR: 0.752, 95% CI: (0.698, 0.810),
) reduced the risk of GDM. The factors influencing GDM included
, prepregnancy overweight or obese, FHD, history of GDM, macrosomia, stillbirth, premature delivery, pregestational smoking, and primigravida.
Funder
Key Clinical Specialty Development Project of Chongqing
Subject
Endocrinology,Endocrinology, Diabetes and Metabolism