Antidiabetic Activity ofVinca roseaExtracts in Alloxan-Induced Diabetic Rats-Reference-Cited by-同舟云学术

Antidiabetic Activity ofVinca roseaExtracts in Alloxan-Induced Diabetic Rats

Published:2010 Issue: Volume:2010 Page:1-6
ISSN:1687-8337
Container-title:International Journal of Endocrinology
language:en
Short-container-title:International Journal of Endocrinology

Author:

Ahmed Mohammed Fazil¹²,Kazim Syed Mohammed¹²,Ghori Syed Safiullah¹²,Mehjabeen Syeda Sughra¹²,Ahmed Shaik Rasheed¹²,Ali Shaik Mehboob³,Ibrahim Mohammed¹²

Affiliation:

1. Department of Pharmacology and Biotechnology, Nizam Institute of Pharmacy, Deshmukhi, Pochampally (M), Near Ramoji Film City, Nalgonda 508284, Andhra Pradesh, India

2. Center for Liver Research and Diagnostics, Deccan College of Medical Sciences and Allied Hospitals Kanchanbagh, Hyderabad 500 058, Andhra Pradesh, India

3. Department of Microbiology, Moana Marine Biotech Ltd., Vishakapatnam 530027, Andhra Pradesh, India

Abstract

The present study was carried out to evaluate the antidiabetic activity ofVinca roseamethanolic whole plant extracts in alloxan induced diabetic rats for 14 days. The methanolic whole plant extract at high dose (500 mg/kg) exhibited significant anti-hyperglycemic activity than whole plant extract at low dose (300 mg/kg) in diabetic rats. The methanolic extracts also showed improvement in parameters like body weight and lipid profile as well as regeneration ofβ-cells of pancreas in diabetic rats. Histopathological studies reinforce the healing of pancreas, by methanolicVinca roseaextracts, as a possible mechanism of their antidiabetic activity.

Publisher

Hindawi Limited

Subject

Endocrine and Autonomic Systems,Endocrinology,Endocrinology, Diabetes and Metabolism

Link

http://downloads.hindawi.com/journals/ije/2010/841090.pdf

Reference27 articles.

1. Ethanolic extract of Ocimum sanctum leaves partially attenuates streptozotocin-induced alterations in glycogen content and carbohydrate metabolism in rats

2. Anti-Diabetic Activity of Fruits of Terminalia chebula on Streptozotocin Induced Diabetic Rats

3. Antihyperglycemic activity of Momordica cymbalaria in alloxan diabetic rats

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