Affiliation:
1. Department of Pharmacology, Institute of Biosciences, São Paulo State University (UNESP), 18618-000 Botucatu, SP, Brazil
2. Department of Morphology, Institute of Biosciences, São Paulo State University (UNESP), 18618-000 Botucatu, SP, Brazil
Abstract
The present study aimed to clarify the role of mast cells in colitis with relapse induced in Wistar rats by trinitrobenzenosulphonic acid. Colitis induction increased the histamine concentration in the colon, which peaked on day 26. The number of mast cells, probably immature, was ten times higher on day 8. Different from animals infected with intestinal parasites, after colitis remission, mast cells do not migrate to the spleen, showing that mast cell proliferation presents different characteristics depending on the inflammation stimuli. Treatment with sulfasalazine, doxantrazole, quercetin, or nedocromil did not increase the histamine concentration or the mast cell number in the colon on day 26, thereby showing absence of degranulation of these cells. In conclusion, although mast cell proliferation is associated with colitis, these cells and their mediators appear to play no clear role in the colitis with relapses.
Funder
Fundação de Amparo à Pesquisa do Estado de São Paulo
Cited by
8 articles.
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