Affiliation:
1. School of Health and Allied Sciences, Faculty of Health Sciences, Pokhara University, Pokhara 33700, Kaski, Nepal
Abstract
Ocimum tenuiflorum L. is found throughout semitropical and tropical parts of Southeast Asia. In Nepal, O. tenuiflorum L. is popular with two variants: Krishna Tulsi consisting of purple-colored leaves and Sri Tulsi consisting of green-colored leaves. O. tenuiflorum L. is considered the queen of herbs and is a traditionally and clinically proven medicinal herb for its application and efficacy. However, no commercial pharmaceutical preparations of O. tenuiflorum L. are available using effervescent vehicles. Therefore, the present study aimed to compare the antioxidant activity of leaves from the two varieties of O. tenuiflorum L. and formulate and evaluate the quality parameters of effervescent granules of the potent extract. The antioxidant activity of O. tenuiflorum L. ethanolic extracts was evaluated by DPPH radical scavenging assay at 1, 10, and 100 µg/mL concentrations, where ascorbic acid was used as the positive control. The antioxidant activity of purple-leafed O. tenuiflorum L. was found to be higher than that of green-leafed O. tenuiflorum L. Therefore, effervescent granules of the ethanolic extract of purple-leafed O. tenuiflorum L. were formulated using the pharmaceutical excipients tartaric acid, citric acid, and sodium bicarbonate and the quality parameters of the granules were evaluated. The formulated granules met the quality parameters assessed from the angle of repose, bulk density, tapped density, Carr’s Index, Hausner’s ratio, effervescent cessation time, and stability studies. Thus, the formulated effervescent granules of O. tenuiflorum L. can be used for therapeutic purposes or as a functional food.
Funder
Pokhara University Research Center
Subject
General Environmental Science,General Biochemistry, Genetics and Molecular Biology,General Medicine
Reference41 articles.
1. Plant‐mediated synthesis of nanoparticles and their antimicrobial activity against phytopathogens
2. Biological activities and phenolic contents of Rumex scutatus collected from Turkey;O. Unal;Fresenius Environmental Bulletin,2022
3. Physiological properties and phytochemical composition of endemic Origanum boissieri;I. Uysal;Fresenius Environmental Bulletin,2020
4. Tulsi - Ocimum sanctum: A herb for all reasons
5. Ocimum sanctum Linn. extract improves cognitive deficits in olfactory bulbectomized mice via the enhancement of central cholinergic systems and VEGF expression;X. T. Le;Evidence-Based Complementary and Alternative Medicine,2021
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