Vascular Endothelial Growth Factor Single Nucleotide Polymorphism +405 G/C (rs2010963) is associated with Levels, Infection Severity, and Amputation among South Indian Diabetic Foot Ulcer Patients

Author:

Ganapathy Priyanka1ORCID,Devanatha Desikan Sheshadri Vidya2,Sarkar Rajesh3,Jones Sumathi4ORCID,Gunasekaran Krishnamoorthy5ORCID,Feyisa Teka Obsa6,Umapathy Dhamodharan78ORCID,Basha Saleem6ORCID

Affiliation:

1. Department of Physiology, Sree Balaji Medical College and Hospital, Chennai, Tamilnadu, India

2. Department of Pharmacology and Toxicology, College of Pharmacy (Women’s Campus), Prince Sattam Bin Abdul Aziz University, Al-Kharj, Saudi Arabia

3. Department of Medical Microbiology, College of Health and Medical Sciences, Haramaya University, Dire Dawa, Ethiopia

4. Department of Pharmacology and Therapeutics, Sree Balaji Dental College and Hospital, Chennai, Tamilnadu, India

5. Department of Medical Biochemistry, College of Medical and Health Sciences, Dambi Dollo University, Oromia Region, Ethiopia

6. Department of Medical Biochemistry, College of Health and Medical Sciences, Haramaya University, Dire Dawa, Ethiopia

7. Department of Biotechnology, D.K.M. College for Women, Vellore, Tamil Nadu, India

8. Department of Research, APRAISE, Adhiparasakthi Dental College and Hospital, Melmaruvathur, Tamilnadu, India

Abstract

Background. The regulation of vascular endothelial growth factor (VEGF) by genetic factors in T2DM and DFU still requires thorough investigation. Hence, the present study aimed to investigate the association of VEGF +405 G/C in DFU subjects and correlate it with its circulatory levels, infection severity, and amputation rate. Materials and Methods. This study registered a total of 754 participants of which group I: healthy controls (n = 297), group II: T2DM subjects (n = 242), and group III: DFU subjects (n = 215). Genotyping and levels of rs2010963 were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and ELISA, respectively. Results. Results of the current study showed a clear decline in circulatory VEGF-A levels in DFU subjects. VEGF-A was decreased in DFU subjects with the mutant “CC” genotype. The mutant “CC” of VEGF +405G/C was also found to be more susceptible to ulcer grade (III and IV) and major amputations. Conclusion. VEGF +405G/C SNP is associated with levels, infection severity, and amputation amongst South Indian DFU patients.

Publisher

Hindawi Limited

Subject

Complementary and alternative medicine

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