Affiliation:
1. Department of Pediatrics, Medical Faculty, Firat University, Elazig, 23119, Turkey
2. Department of Biochemistry, Medical Faculty, Firat University, Elazig, 23119, Turkey
Abstract
It has not yet been shown in prepubertal children how cytokines, leptin, and body mass, as well as parameters of obesity are interrelated. The aim of this study was to explore the relation between circulating levels of some cytokines with leptin and body mass index. A case control study was carried out in obese children of both sexes. An obese group was carried out with 63 school prepubertal children and a control group comprised the same number of nonobese children paired by age and by sex. Mean serum leptin concentration was significantly higher in the obese children at19.9±7.4ng/mL, than the control group (7.9±5.1ng/mL). Serum IL-1β, IL-6, and TNF-αlevels were also significantly higher in the obese group than controls (33.0±8.9,45.2±11.8, and9.2±2.3pg/mL, versus3.6±1.0,13.1±3.9, and3.9±1.0pg/mL, resp). In controversy, serum IL-2 level was diminished in the obese group as0.4±0.1versus0.9±0.1U/L. Obesity may be a low-grade systemic inflammatory disease. Obese prepubertal children have elevated serum levels of IL-1β, IL-6, and TNF-αwhich are known as markers of inflammation.
Cited by
82 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献