Detection of Biomolecules and Glucose Concentration in Blood Using a Subwavelength Grating Optical Biosensor

Abstract

The research paper describes the design and simulation of an optical biosensor based on a ring resonator with a strip waveguide and a subwavelength grating waveguide. The main goal of the device is to function in low-loss regions and prevent bending losses in ring resonator configuration. The finite-difference-time-domain analysis is performed to simulate the device and to observe the sensing parameters. The biosensor is intended to be used for sensing biological molecules. The working principle of the sensor is to detect changes in the resonant wavelength caused by changes in the refractive index of biomaterials. By observing the shift in the resonant wavelength, the sensor can provide sensitive and reliable detection of biomolecules in solution. The evaluated sensitivity of the device is 206.3 nm/RIU, with a limit of detection of the order of 10−5 RIU. The device is also tested for the detection of glucose concentration in blood and found to be well-suited for on-chip applications. This makes it a promising candidate for use in a wide range of biosensing applications, from medical diagnostics to food safety testing.