A Novel Artificial Intelligence System in Formulation Dissolution Prediction

Abstract

Artificial neural network (ANN) techniques are widely used to screen the data and predict the experimental result in pharmaceutical studies. In this study, a novel dissolution result prediction and screen system with a backpropagation network and regression methods was modeled. For this purpose, 21 groups of dissolution data were used to train and verify the ANN model. Based on the design of input data, the related data were still available to train the ANN model when the formulation composition was changed. Two regression methods, the effective data regression method (EDRM) and the reference line regression method (RLRM), make this system predict dissolution results with a high accuracy rate but use less database than the orthogonal experiment. Based on the decision tree, a data screen function is also realized in this system. This ANN model provides a novel drug prediction system with a decrease in time and cost and also easily facilitates the design of new formulation.