Chemokines and Chemokine Receptors in the Development of Lupus Nephritis

Author:

Liao Xiaofeng1ORCID,Pirapakaran Tharshikha1ORCID,Luo Xin M.1ORCID

Affiliation:

1. Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA

Abstract

Lupus nephritis (LN) is a major cause of morbidity and mortality in the patients with systemic lupus erythematosus (SLE), an autoimmune disease with damage to multiple organs. Leukocyte recruitment into the inflamed kidney is a critical step to promote LN progression, and the chemokine/chemokine receptor system is necessary for leukocyte recruitment. In this review, we summarize recent studies on the roles of chemokines and chemokine receptors in the development of LN and discuss the potential and hurdles of developing novel, chemokine-based drugs to treat LN.

Publisher

Hindawi Limited

Subject

Cell Biology,Immunology

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