Affiliation:
1. Key Laboratory of OptoElectronic Science and Technology for Medicine, Ministry of Education, and Fujian Provincial Key Laboratory for Photonics Technology, Fujian Normal University, Fujian 350007, China
Abstract
The aim of this study is to develop a light-emitting diode- (LED-) based illumination system that can be used as an alternative light source forin vitrophotodynamic therapy (PDT). This illumination system includes a red LED array composed of 70 LEDs centered at 643 nm, an air-cooling unit, and a specific-designed case. The irradiance as a function of the irradiation distance between the LED array and the sample, the homogeneity and stability of irradiation, and the effect of long-time irradiation on culture medium temperature were characterized. Furthermore, the survival rate of the CNE1 cells that sensitized with 5-aminolevulinic acid after PDT treatment was evaluated to demonstrate the efficiency of the new LED-based illumination system. The obtained results show that the LED-based illumination system is a promising light source forin vitroPDT that performed in standard multiwell plate.
Funder
National Natural Science Foundation of China
Subject
General Materials Science,Renewable Energy, Sustainability and the Environment,Atomic and Molecular Physics, and Optics,General Chemistry
Cited by
33 articles.
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