Extraction of Radix trichosanthis Polysaccharides for Potential Antihyperlipidemic Application

Author:

Chen Fujia1ORCID,Xu Yilin2,Ding Nana1,Li Hongyan1ORCID,Li Tongbiao1,Liu Fengyun1,Liang Mengxue1,Song Li1,Liu Junhe1,Li Enzhong1,Liu Jiayang3ORCID

Affiliation:

1. College of Biology and Food Engineering, Huanghuai University, Zhumadian 463000, China

2. College of Plant Protection, Henan Agricultural University, Zhengzhou 450046, China

3. School of Environmental Science and Engineering, Nanjing Tech University, Nanjing 211816, China

Abstract

This study focused on the optimization of ultrasound-assisted compound enzyme extraction for polysaccharides (RTPs) from Radix trichosanthis by orthogonal experiment and response surface methodology, and then its extraction kinetics model and antihyperlipidemic activities were studied. The optimum extraction process was as follows: cellulase—1.0%, papain—1.0%, pectase—0.5%, pH—5, extraction temperature—50°C, and liquid-to-solid ratio—30 mL/g; prediction value of RTPs was 7.54%; the experimental yield of RTPs was 7.22%, while 50 minutes was optimized in Weibull kinetics model. Then high-dose groups of RTP extract could reduce the TC, TG, and LDL-C levels and increase the level of HDL-C in high-fat mice, with the ability to lower the MDA content and enhance SOD level.

Funder

Scientific and Technological Research Project Foundation of Henan Provincial Scientific and Technological Department

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

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