Mechanisms of Aminoglycoside Ototoxicity and Targets of Hair Cell Protection-Reference-Cited by-同舟云学术

Mechanisms of Aminoglycoside Ototoxicity and Targets of Hair Cell Protection

Published:2011 Issue: Volume:2011 Page:1-19
ISSN:1687-9201
Container-title:International Journal of Otolaryngology
language:en
Short-container-title:International Journal of Otolaryngology

Author:

Huth M. E.¹²,Ricci A. J.¹³,Cheng A. G.¹

Affiliation:

1. Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA 94305-5739, USA

2. Department of Otorhinolaryngology, Head and Neck Surgery, Inselspital, University of Bern, Freiburgstrasse, 3010 Bern, Switzerland

3. Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA

Abstract

Aminoglycosides are commonly prescribed antibiotics with deleterious side effects to the inner ear. Due to their popular application as a result of their potent antimicrobial activities, many efforts have been undertaken to prevent aminoglycoside ototoxicity. Over the years, understanding of the antimicrobial as well as ototoxic mechanisms of aminoglycosides has increased. These mechanisms are reviewed in regard to established and potential future targets of hair cell protection.

Funder

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Publisher

Hindawi Limited

Link

http://downloads.hindawi.com/journals/ijoto/2011/937861.pdf

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