Acupuncture Combined with Three-Step Analgesic Drug Therapy for Treatment of Cancer Pain: A Systematic Review and Meta-Analysis of Randomised Clinical Trials

Author:

Li De-hui1ORCID,Su Yi-fan12ORCID,Fan Huan-fang1,Guo Na1,Sun Chun-xia1

Affiliation:

1. Hebei Province Hospital of Chinese Medicine, The First Affiliated Hospital of Hebei University of Chinese Medicine, Shijiazhuang 050011, China

2. Graduate School of Hebei University of Chinese Medicine, Shijiazhuang 050091, China

Abstract

Objective. The purpose of this study was to systematically evaluate the efficacy and safety of acupuncture combined with the WHO three-step analgesic drug ladder for cancer pain. Methods. The Cochrane Library, PubMed, and CNKI Database of Systematic Reviews were searched. Using the Cochrane Register for Randomized Controlled Trials, the quality of the included literature was evaluated, and the meta-analysis was carried out with RevMan 5.3 software. Results. Compared with three-step analgesia alone, acupuncture combined with three-step analgesia for cancer pain increased pain relief response rates (RR = 1.12, 95% CI: 1.08∼1.17, P < 0.00001 ), reduced NRS score (SMD = −1.10, 95% CI: −1.86∼−0.35, P = 0.004 ), reduced the rate of side effects (RR = 0.45, 95% CI: 0.38∼0.53, P < 0.00001 ), including nausea ( P < 0.00001 ), vomiting ( P = 0.008 ), constipation ( P < 0.00001 ), and dizziness ( P = 0.010 ), reduced the burst pain rate (SMD = −1.38; 95% CI: −2.44∼−0.32, P = 0.01 ), shortened analgesia effect onset time ( P = 0.004 ), and extended the duration of response ( P < 0.0001 ). Conclusion. For the treatment of cancer pain, acupuncture combined with three-step analgesic drugs is better than using only three-step analgesic drugs.

Funder

National Natural Science Foundation of China

Publisher

Hindawi Limited

Subject

Complementary and alternative medicine

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