Effect of General Cross-Immunity Protection and Antibody-Dependent Enhancement in Dengue Dynamics

Abstract

A mathematical model to describe the dynamic of a multiserotype infectious disease at the population level is studied. Applied to dengue fever epidemiology, we analyse a mathematical model with time delay to describe the cross-immunity protection period, including a key parameter for the antibody-dependent enhancement (ADE) effect, the well-known features of dengue fever infection. Numerical experiments are performed to show the stability of the coexistence equilibrium, which is completely determined by the basic reproduction number and by the invasion reproduction number, as well as the bifurcation structures for different scenarios of dengue fever transmission in a population. The model shows a rich dynamical behavior, from fixed points and periodic oscillations up to chaotic behaviour with complex attractors.