A Direct Sulfation Process of a Marine Polysaccharide in Ionic Liquid

Author:

Chopin Nathalie12ORCID,Sinquin Corinne1,Ratiskol Jacqueline1,Zykwinska Agata1ORCID,Weiss Pierre3,Cérantola Stéphane4,Le Bideau Jean2,Colliec-Jouault Sylvia1ORCID

Affiliation:

1. IFREMER, Institut Français de Recherche pour l’Exploitation de la Mer, Laboratoire Ecosystèmes Microbiens et Molécules Marines pour les Biotechnologies, rue de l’île d’Yeu, BP 21105, 44311 Nantes Cedex 03, France

2. Institut des Matériaux Jean Rouxel (IMN), Université de Nantes, CNRS, 2 rue de la Houssinière, BP 32229, 44322 Nantes Cedex 3, France

3. INSERM U791, Laboratoire d’Ingénierie Ostéo-Articulaire et Dentaire (LIOAD), Université de Nantes, 1 place Alexis Ricordeau, BP 84215, 44042 Nantes Cedex 1, France

4. Laboratoire de Résonance Magnétique Nucléaire, Université de Bretagne Occidentale, CS 93837, 29238 Brest Cedex 3, France

Abstract

GY785 is an exopolysaccharide produced by a mesophilic bacterial strainAlteromonas infernusdiscovered in the deep-sea hydrothermal vents. GY785 highly sulfated derivative (GY785 DRS) was previously demonstrated to be a promising molecule driving the efficient mesenchymal stem cell chondrogenesis for cartilage repair. This glycosaminoglycan- (GAG-) like compound was modified in a classical solvent (N,N′-dimethylformamide). However, the use of classical solvents limits the polysaccharide solubility and causes the backbone degradation. In the present study, a one-step efficient sulfation process devoid of side effects (e.g., polysaccharide depolymerization and/or degradation) was developed to produce GAG-like derivatives. The sulfation of GY785 derivative (GY785 DR) was carried out using ionic liquid as a reaction medium. The successful sulfation of this anionic and highly branched heteropolysaccharide performed in ionic liquid would facilitate the production of new molecules of high specificity for biological targets such as tissue engineering or regenerative medicine.

Funder

BIOREGOS II Network

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

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