Ectopic Cushing’s Syndrome Secondary to Metastatic Paraganglioma

Author:

Daya R.12ORCID,Wingfield C.1ORCID,Sotshononda P.1ORCID,Seedat F.12ORCID,Bulbulia S.12ORCID,Simmons M. D.3ORCID,Louw M.3ORCID,Bayat Z.12ORCID

Affiliation:

1. Division of Endocrinology and Metabolism, Department of Internal Medicine, Helen Joseph Hospital, 1 Perth Road, Rossmore, Johannesburg, South Africa

2. Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Health Sciences, School of Clinical Medicine, University of the Witwatersrand, Johannesburg, South Africa

3. Department of Anatomical Pathology, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa

Abstract

Paraneoplastic or ectopic Cushing’s syndrome (CS) is a rare cause of endogenous hypercortisolism. It is due to ectopic adrenocorticotropic hormone (ACTH) secretion and has been reported in association with a variety of neuroendocrine tumors such as small-cell lung carcinoma, carcinoid tumors, and medullary carcinoma of the thyroid. Paragangliomas (PGLs) are rare neuroendocrine tumors that can secrete catecholamines. Case reports and reports of ectopic ACTH secretion from metastatic PGLs causing CS are exceedingly rare. We present a case of a 38-year-old female, who presented with typical signs, symptoms, and complications of CS, secondary to a PGL with widespread metastases, which eventually led to her demise.

Publisher

Hindawi Limited

Subject

Endocrinology, Diabetes and Metabolism

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