An Efficient Green Procedure for Synthesis of Some Fluorinated Curcumin Analogues Catalyzed by Calcium Oxide under Microwave Irradiation and Its Antibacterial Evaluation

Abstract

A series of fluorine substituted curcumin analogues have been synthesized in a cheaper and greener method using calcium oxide as catalyst under microwave irradiation. All the synthesized compounds have been characterized by FT-IR, MS, elemental analysis, and1H and13C NMR spectroscopic techniques and screened for antibacterial activities againstStaphylococcus aureus,β-Heamolytic streptococcus,Shigella flexneri,Vibrio cholerae,Pseudomonas aeruginosa, andKlebsiella pneumonia. All the synthesized compounds are showing good zone of inhibition against the tested bacterial strains.